Effects of levodopa on regional cerebral metabolism and blood flow.
Identifieur interne : 000250 ( Main/Exploration ); précédent : 000249; suivant : 000251Effects of levodopa on regional cerebral metabolism and blood flow.
Auteurs : Ji Hyun Ko [États-Unis] ; Renata P. Lerner ; David EidelbergSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
English descriptors
- KwdEn :
- Animals, Antiparkinson Agents (pharmacology), Antiparkinson Agents (therapeutic use), Cerebral Cortex (blood supply), Cerebral Cortex (drug effects), Cerebral Cortex (metabolism), Cognition Disorders (drug therapy), Cognition Disorders (etiology), Humans, Levodopa (pharmacology), Levodopa (therapeutic use), Neuroimaging, Parkinson Disease (complications), Parkinson Disease (drug therapy), Regional Blood Flow (drug effects).
- MESH :
- chemical , pharmacology : Antiparkinson Agents, Levodopa.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- blood supply : Cerebral Cortex.
- complications : Parkinson Disease.
- drug effects : Cerebral Cortex, Regional Blood Flow.
- drug therapy : Cognition Disorders, Parkinson Disease.
- etiology : Cognition Disorders.
- metabolism : Cerebral Cortex.
- Animals, Humans, Neuroimaging.
Abstract
Levodopa (L-dopa) has been at the forefront of antiparkinsonian therapy for a half century. Recent advances in functional brain imaging have contributed substantially to the understanding of the effects of L-dopa and other dopaminergic treatment on the activity of abnormal motor and cognitive brain circuits in Parkinson's disease patients. Progress has also been made in understanding the functional pathology of dyskinesias, a common side effect of l-dopa treatment, at both regional and network levels. Here, we review these studies, focusing mainly on the new mechanistic insights provided by metabolic brain imaging and network analysis.
DOI: 10.1002/mds.26041
PubMed: 25296957
Affiliations:
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Le document en format XML
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Lerner</name></author><author><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiparkinson Agents (pharmacology)</term><term>Antiparkinson Agents (therapeutic use)</term><term>Cerebral Cortex (blood supply)</term><term>Cerebral Cortex (drug effects)</term><term>Cerebral Cortex (metabolism)</term><term>Cognition Disorders (drug therapy)</term><term>Cognition Disorders (etiology)</term><term>Humans</term><term>Levodopa (pharmacology)</term><term>Levodopa (therapeutic use)</term><term>Neuroimaging</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (drug therapy)</term><term>Regional Blood Flow (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Cerebral Cortex</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cerebral Cortex</term><term>Regional Blood Flow</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Cognition Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cerebral Cortex</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Neuroimaging</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Levodopa (L-dopa) has been at the forefront of antiparkinsonian therapy for a half century. Recent advances in functional brain imaging have contributed substantially to the understanding of the effects of L-dopa and other dopaminergic treatment on the activity of abnormal motor and cognitive brain circuits in Parkinson's disease patients. Progress has also been made in understanding the functional pathology of dyskinesias, a common side effect of l-dopa treatment, at both regional and network levels. Here, we review these studies, focusing mainly on the new mechanistic insights provided by metabolic brain imaging and network analysis.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><noCountry><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name><name sortKey="Lerner, Renata P" sort="Lerner, Renata P" uniqKey="Lerner R" first="Renata P" last="Lerner">Renata P. Lerner</name></noCountry><country name="États-Unis"><region name="État de New York"><name sortKey="Ko, Ji Hyun" sort="Ko, Ji Hyun" uniqKey="Ko J" first="Ji Hyun" last="Ko">Ji Hyun Ko</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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